Endocrine Abstracts

Introduction: In Spain, the specialist in endocrinology and nutrition is the reference in the care of patients with diabetes mellitus. In the year 2022, access to these specialists has been facilitated in the south of Gran Canaria. The aim of the study is to determine how this has influenced the management of type 2 diabetes (T2D).Methods: We included those patients with T2D assessed by the Endocrinology service in 2022 in which two analyses were perform...

Introduction: Non-classical congenital adrenal hyperplasia (NCCAH) due to 21-hydroxylase deficiency is one of the most frequent autosomal recessive diseases. Genetic analysis performed for genetic counselling revealed a miscorrelation with the clinical diagnosis in several patients at our centre.Aim: Confirm the genetic diagnosis of NCCAH in women attended for this condition.Materials and methods: Consecutive patients attended at o...

Objectives: To evaluate satisfaction with treatment in diabetic patients under therapy with inhaled insulin (exubera).Material and methods: Thirty-seven diabetic patients were evaluated, 27DM1 (75%) and 9DM2 (25%) that initiated treatment with Insulin inhaled (EXUBERA) between August and October 2007. Twenty-five men (69.4%) and 11 women (30.56%), between 18 and 71 years old (38.4±16.4) and with a time of evolution of diabetes between 0 and 47 years...

Objectives: To value the quality of life improvement and metabolic control in patients with DM1 in the 2 first years of treatment with insulin pump therapy.Material and methods: We studied 33 DM1 patients, 16 men (48.5%) and 17 women (51.5%), with average age of 34.2±12.2 and 16.3±10.21 years of disease. Pump indication was hypoglycemia in 10 (30.3%), badly metabolic control in 14 (42.4%), pregnancy in 5 (15.2%) and glycemic inestability in 4 (...

We aimed to assess the effect of sleeve gastrectomy (SG) on the metabolic and gut microbiota profiles in non-diabetic obese patients with different grade of insulin resistance (IR).Methods: Prospective study of 22 morbid non-diabetic obese patients (77.2% women, age 47.13±9.51 years, basal BMI 45.59±4.99 kg/m2, 11 IR and 11 non-IR) undergoing SG. A fasting blood sample was collected at baseline and at 6 months post-SG for the determi...

Hemoglobin A1c (HbA1c) is used for the long-term management of patients with diabetes mellitus (DM). Hemoglobin variants other than HbA1c and e-N-lysine-glycated HbA0 may cause analytical interference in determinations of HbA1c. Hemoglobin J is an abnormal hemoglobin, an alpha globin gene variant and present in various geographic locations. Hemoglobin J (depending on its type) has different characteristics and functions. For example hemoglobin J Capetown (α2 92Gln β2...

Introduction: Zinc transporter 8 (ZnT8) autoimmunity has been established as one of the markers for the diagnosis of type 1 diabetes (T1D) along with glutamate decarboxylase (GAD) and tyrosine phosphatase IA-2 (IA-2) antibodies. The aim of this study is to understand the status of pancreatic autoimmunity in the diagnosis of T1D, with special attention to the usefulness of ZnT8. In addition, as a second objective, we study the proposal to perform the assessment of pancreatic au...

Introduction: ISCI treatment is useful to optimize treatment in patients with DM1. Before implantation, is necessary the education of patients, as in technical aspects so in the handling of diabetes with this therapy.Objective: Evaluate the results of the diabetological education previous to the implantation of the ISCI and the repercussion of this program in patients metabolic control.Material and method: Forty-seven diabetic pati...

Introduction: Isolated ACTH failure is a rare disorder characterized by a secondary adrenal failure and a considerable deterioration of the general state. In adults the has been established related to cranial traumatism and to autoimmune hypophysitis (AH). It has been pointed out that the isolated failure of pituitary tropin in the context of a AH, could end with a global pituitary failure.Objective: Evaluation of the shortage of isolated ACTH as a way o...

Introduction: The accomplishment of screening neonatal congenital hypothyroidism allows the use of the determination of TSH in new born (NB) like indirect marker of the iodine ingestion of the pregnant woman and the nutritional iodine deficiency in the population. In populations with a sufficient iodine ingestion, the proportion of children with TSH superior to 5 U/ml is smaller of 3%.Primary target: To make the iodine deficiency map in the studied area ...